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Generic Name: Sodium clodronate
Product Name: Bonefos


Bonefos is used in some cancers to reduce bone destruction that could result in bone pain and fractures.It is also used to bring down high calcium blood levels to normal as well as maintain normal calcium blood levels.


Bonefos contains Clodronate. It works by preventing calcium from coming out of bones, therefore reducing the risk of fractures as well as maintaining normal levels of calcium in the blood.This is important for some cancer as they can cause calcium to come out of the bone making bone weaker and increasing the risk of fractures and pain as well as elevated calcium blood levels.

Dose advice

  • Bonefos is only available via a prescription from the doctor.
  • Consult your doctor before taking this medication if you are currently pregnant or breastfeeding or planning to get pregnant soon. It is important to weigh the benefits and risks of taking this medication during this time.
  • Swallow the tablets or capsules whole with a full glass of plain water.
  • The 800mg tablet is scored and can be broken into half if necessary.
  • It is preferred to take bonefos in the morning on an empty stomach at least 2 hours before taking any food or drink (except for water) as they may reduce absorption and effectiveness.
  • After taking a dose of bonefos, it is important not to eat anything for about 1 hour.
  • It is also important not to take antacids, calcium, iron or mineral supplements within 2 hours of taking bonefos as they may interfere with its absorption and effectiveness.


Schedule 4

Common side effects

All medicines have side effects. Some side effects can be serious, but the most common ones are mild.

Common side effects occurring in more than 1% of patients prescribed Bonefos include:

Consult your doctor if you experience any side effects.

Uncommon side effects

These are some side effects that occur in less than 1% of patients and are uncommon. Do not be alarmed by this list, they are uncommon side effects and a patient will not necessarily experience any of these:

Consult your doctor if you experience any of the above side effects or any other unusual or abnormal symptoms.


  1. Australian Medicines Handbook. Bonefos. [Monograph online]AMH Pty Ltd 2007. [Cited October 29, 2007]. Available from: [URL Link]
  2. Bonefos. MIMS Online. [Monograph online] MIMS Australia Pty Ltd 2007. [Cited October 29, 2007]. Available from: [URL Link]
  3. Lazo, J, Gilman A, Brunton L, Parker K. Goodman & Gilman’s the pharmacological basis of therapeutics.11th ed. New York: McGraw-Hill; 2005

For further information talk to your doctor.


Posted On: 22 July, 2003
Modified On: 31 January, 2016
Reviewed On: 7 November, 2007


Created by: myVMC