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Baclofen (Terry White Chemists)

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Generic Name: Baclofen
Product Name: Baclofen (Terry White Chemists)

Indication

  • Baclo may be used in the suppression of muscle spasms in patients with multiple sclerosis.
  • It may also be used in the management of patients with spinal cord lesions of traumatic, infective, degenerative and malignant origins, which may have caused muscle and bladder dysfunction.

Action

  • Baclo is an antispastic agent that acts on the spinal cord.
  • It also acts as a central nervous system depressant.
  • It depresses monosynaptic and polysynaptic reflex transmission, most likely due to the stimulation on GABAB receptors which inturn inhibit the release of excitatory amino acids (e.g. glutamate and aspartate) – hence lessening nerve impulses to muscles in spasm.
  • Baclo also has an antinociceptive effect (pain relief) however the mechanism by which this occurs is not yet known.

Dose advice

  • Small doses should be initially administered, which gradually increase in a stepwise manner according to the patients symptoms.
  • Baclo should be taken with meals and a glass of water.
  • Treatment usually involves 3 divided doses daily and initially doses should be in the range of 5mg three times daily. The dose is subsequently increased by 5mg three times daily every 3 days or until the desired response is achieved.
  • Optimum dosage range is usually 30-75mg daily, however the daily dosage should be individually tailored to the patient according to their requirements.

Schedule

S4

Common side effects

  • Mainly occur at the start of treatment and may be due to a rapidly increased dosage, a too large dose or due to the patients other health problems (e.g. kidney failure)
  • These all can be alleviated by reducing the dose. Some side effects may include:
  • paradoxical increase in spasticity
  • lowered blood pressure
  • nausea
  • constipation
  • diarrhoea
  • vomiting
  • dryness of mouth
  • muscle pain
  • muscle weakness
  • sedation and drowsiness
  • headache
  • mental confusion
  • insomnia
  • euphoria
  • visual disturbances
  • increased sweating
  • skin rash
  • pain on urinating
  • increase urine frequency

Uncommon side effects

  • psychiatric disturbances
  • abnormal heart rhythms
  • shortness of breath
  • palpitations
  • chest pain
  • ankle swelling
  • abdominal pain
  • liver disorders
  • numbness
  • joint pain
  • ‘blackouts’ or short fainting spells
  • taste disturbances
  • urine retention
  • impotence
  • blood in urine
  • nasal congestion
  • weight gain

For further information talk to your doctor.

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Dates

Posted On: 22 July, 2003
Modified On: 29 May, 2008

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Created by: myVMC