Generic Name: Baclofen
Product Name: Baclofen (Terry White Chemists)
- Baclo may be used in the suppression of muscle spasms in patients with multiple sclerosis.
- It may also be used in the management of patients with spinal cord lesions of traumatic, infective, degenerative and malignant origins, which may have caused muscle and bladder dysfunction.
- Baclo is an antispastic agent that acts on the spinal cord.
- It also acts as a central nervous system depressant.
- It depresses monosynaptic and polysynaptic reflex transmission, most likely due to the stimulation on GABAB receptors which inturn inhibit the release of excitatory amino acids (e.g. glutamate and aspartate) – hence lessening nerve impulses to muscles in spasm.
- Baclo also has an antinociceptive effect (pain relief) however the mechanism by which this occurs is not yet known.
- Small doses should be initially administered, which gradually increase in a stepwise manner according to the patients symptoms.
- Baclo should be taken with meals and a glass of water.
- Treatment usually involves 3 divided doses daily and initially doses should be in the range of 5mg three times daily. The dose is subsequently increased by 5mg three times daily every 3 days or until the desired response is achieved.
- Optimum dosage range is usually 30-75mg daily, however the daily dosage should be individually tailored to the patient according to their requirements.
Common side effects
- Mainly occur at the start of treatment and may be due to a rapidly increased dosage, a too large dose or due to the patients other health problems (e.g. kidney failure)
- These all can be alleviated by reducing the dose. Some side effects may include:
- paradoxical increase in spasticity
- lowered blood pressure
- dryness of mouth
- muscle pain
- muscle weakness
- sedation and drowsiness
- mental confusion
- visual disturbances
- increased sweating
- skin rash
- pain on urinating
- increase urine frequency
Uncommon side effects
- psychiatric disturbances
- abnormal heart rhythms
- shortness of breath
- chest pain
- ankle swelling
- abdominal pain
- liver disorders
- joint pain
- ‘blackouts’ or short fainting spells
- taste disturbances
- urine retention
- blood in urine
- nasal congestion
- weight gain
For further information talk to your doctor.