Augmentin Duo Forte

Generic Name: Amoxycillin trihydrate; Potassium clavulanate
Product Name: Augmentin Duo Forte

Indication

• Hospital acquired pneumonia
• Epididymo-orchitis
• Recurrent urinary tract infection
• Bites and clenched fist injuries
• Otitis media (unresponsive to amoxicillin)

Action

• Bactericidal; penicillins interfere with bacterial cell wall peptidoglycan synthesis.
• Moderate spectrum penicillins like amoxicillin are active primarily against gram positive organisms
• The addition of clavulanic acid to amoxicillin extends spectrum of activity to cover many beta-lactamse producing gram positive (S. aureus) and gram negative organisms (Moraxella Catarrhalis, H. Influenzae, Proteus spp., E. coli, Klebsiella spp.), including gram negative anaerobes

Dose advice

Doses are based on the amoxicillin component.

Adult:

• 250-500mg every 8 hours (or using Duo�� formulations: 500-875 mg every 12 hours) for 5-10 days

Child:

• 7.5-15mg/kg every 8 hours (or using Duo�� formulations 22.5mg/kg every 12 hours) for 5-10 days

Moderate renal impairment

Adult:

• give normal initial dose then 500mg every 12 hours

Severe renal impairment

Adult:

• give normal initial dose then 500mg every 24 hours

Schedule

S4

Common side effects

Penicillins are generally well tolerated

• Diarrhoea
• Nausea
• Rash
• Urticaria
• Superinfection- especially during prolonged treatment and/or broad spectrum antibiotics
• Transient increases in liver enzymes and bilirubin

Uncommon side effects

• Bronchospasm
• Fever
• Vomiting
• Erythema
• Exfoliative dermatitis
• Angioedema
• Stevens Johnson Syndrome
• Toxic epidermal necrolysis
• Pseudomembranous colitis

For further information talk to your doctor.