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Generic Name: Zafirlukast
Product Name: Accolate


Accolate is a treatment of asthma


Act by antagonizing airway smooth muscle contraction and inflammation

Dose advice

  • 20 mg twice daily at least 1 hour before or 2 hours after meals
  • May be increased up to 40 mg twice daily
  • Pregnancy: Limited experience. ADEC category B1
  • Lactation: Limited experience, should be safe to use


Schedule 4

Common side effects

  • Headache
  • Abdominal pain
  • Diarrhoea
  • Drug interactions:
    • Warfarin: increased INR (monitor INR)
    • Theophylline: possible increase in theophylline concentration (monitor theophylline concentration)
    • Erythromycin: Decreases Zafirlukast concentration (may require larger dose of Zafirlukast)

Uncommon side effects

  • Hepatitis (avoid use in hepatic impairment)
  • Churg-Strauss syndrome
  • Allergic reactions including urticaria, angioedema and anaphylaxis


For further information talk to your doctor.

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Posted On: 22 July, 2003
Modified On: 31 October, 2015


Created by: myVMC