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Xylocard

Generic Name: Lignocaine hydrochloride
Product Name: Xylocard

Indication

- This drug is used in the treatment or prophylaxis (prevention) of life threatening ventricular arrhythmias (abnormal heart rhythms) associated with myocardial infarction (heart attack), general anaesthesia in susceptible patients, digitalis (drug induced) toxicity or following resuscitation after cardiac arrest

Action

- Lignocaine is a membrane stabilising agent, local anaesthetic and antiarrhythmic agent
– It depresses the slow spontaneous depolarization of Purkinje fibres (electrical pathways in the heart), shortens the action potential period (electrical conduction) and refractory period of Purkinje and ventricular cells and depresses membrane responsiveness (hence cardiac conduction velocity) in Purkinje fibres and the ventricular myocardium

Dose advice

Arrhythmias:
– Dosing should be individualized
– Therapeutic serum concentration range is from 5-20micromol/L
– Treatment for ventricular arrhythmias begins with an intravenous injection followed by an intravenous infusion
Preinfusion:
– Intravenous injection should be given initially to obtain therapeutic blood levels rapidly at a dose of 1mg/kg bodyweight.
Infusion:
– A drip rate of 2-4mg/min is recommended
– Infusion duration is normally 2 or more days (at least 24 hours after the last signs of ventricular arrhythmia is evident)

Schedule

S4

Common side effects

- lightheadedness
– nervousness
– euphoria
– confusion
– dizziness
– drowsiness
– disorientation
– visual disturbances
– vomiting
– tremors

Uncommon side effects

- tremors
– convulsions
– psychosis
– difficulty swallowing
– slurred speech
– slow heart rate
– low blood pressure
– allergic reactions

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 22 July, 2003


Created by: myVMC