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Tazocin

Generic Name: piperacillin sodium; tazobactam sodium
Product Name: Tazocin

Indication

Used for the treatment of serious bacterial infections caused by pathogens susceptible to Tazocin.Including: lower respiratory tract infections; urinary tract infections; intra-abdominal infections; skin and connective tissue infections; bacterial septicaemia; gynaecological infections.

Action

Piperacillin is a broad spectrum, semisynthetic penicillin with bactericidal activity (cell wall synthesis inhibitor) against many Gram positive, Gram negative and anaerobic bacteria.Tazobactam is a potent beta lactamase inhibitor, and extends the antibacterial spectrum of piperacillin to include many beta lactamase producing bacteria usually resistant to it.Both components of Tazocin are well absorbed after intramuscular administration.Peak plasma concentrations following intravenous infusion are achieved within minutes of completing the infusion, and within 40-50 minutes after intramuscular injection.Plasma elimination half lives range from 0.7-1.2 following single or multiple doses, and is not affected by dose or duration of infusion. Piperacillin and tazobactam are both widely distributed in tissues and body fluids (including intestinal mucosa, gallbladder, lung and bile).Both Tazocin compounds are primarily renally excreted. Half lives increase with decreasing creatinine clearance, and dose adjustments are recommended when creatinine clearance is < 40 mL/min. (Half lives also increase in patients with hepatic impairment, however dosage adjustments are not required in these patients).

Dose advice

Adults, children > 12 years: Piperacillin 2-4 g/Tazobactam 0.25-0.5 g, every six to eight hours.Children 2-12 years (weighing up to 40 kg, with normal renal function): Piperacillin 100 mg/Tazobactam 12.5 mg per kg, every eight hours.Renal insufficiency:Creatinine clearance > 40 mL/min: no dosage adjustment required.Creatinine clearance 20-40 mL/min: Piperacillin 12 g/Tazobactam 0.5 g per day, in divided doses every 8 hours.Creatinine clearance < 20 mL/min: Piperacillin 8 g/Tazobactam 0.5 g per day, in divided doses every 8 hours.

Schedule

S4

Common side effects

Diarrhoea, vomiting, nausea, dyspepsiaInsomnia.Rash, erythema, itch, urticaria.Superinfection.

Uncommon side effects

Injection site reaction.Soft/loose stools, constipation, bloody diarrhoea, dry mouth, stomatitis.Muscle weakness and weakness.Hypotension, thrombophlebitis, flushing, oedema, rigors, fever.Headache, hallucination, dizziness, fatigue.Eczema, erythema multiforme, Stevens-Johnson syndrome.Transient changes in haematological, and hepatic and renal biochemistry laboratory parameters.

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 30 January, 2014


Created by: myVMC
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