Generic Name: Sulfasalazine
Product Name: Salazopyrin, Salazopyrin EN-tabs
Pyralin is used in the treatment of ulcerative colitis and Crohn’s disease, the inflammatory bowel diseases of unknown cause. It is used in conjunction with dietary and supportive measures and is especially useful in relapse prevention rather than treatment of acute episodes (where topical rectal steroids are more useful). Pyralin EN is also used in the treatment of rheumatoid arthritis that has not responded to NSAID therapy.
The active ingredient in Pyralin is Sulfasalazine, it is helpful in the treatment of the diarrhoea and inflammation associated with ulcerative colitis. It is also useful in the treatment of rheumatoid arthritis.Due to the fact that the causative factors of these diseases are not well understood, the exact way that Sulfasalazine works to treat them is also not fully understood. One component of Sulfasalazine has some anti-inflammatory action, whilst another is able to combat the autoimmune process thought to be occurring in these diseases.
Inflammatory bowel disease:
Pyralin tablets should be taken after meals in evenly divided doses over 24 hours, with no more than 8 hours between doses. The enteric coated (EN) tablets should be swallowed whole, not crushed or chewed. Pyralin EN increases gastrointestinal tolerance to the drug.
- Initial dosage:
- Adults: 1-2g four times daily.
- Children: 40-60mg/kg bodyweight in three to six divided doses daily.
- Maintenance dosage:
- Adults: 2g daily in four divided doses.
- Children: 40mg/kg in four divided doses.
The enteric coated (EN) tablets should be swallowed whole, not crushed or chewed.
- Adults: 2-3 Pyralin EN tablets two or three times daily (i.e: 2-3g daily). It may be necessary to start using the following regime:
- First week: one tablet in the evening.
- Second week: one tablet in the morning and one in the evening.
- Third week: one tablet in the morning and two in the evening.
- Fourth week: two tablets in the morning and two in the evening.
- And so on, to a maximum of 3g per day.
- Children: There is currently no dose advice for use of Pyralin EN in children with rheumatoid arthritis.
Common side effects
Many of the side effects of Pyralin are dose dependent and can therefore be relieved by reducing the dose.
The most common side effects include:
- Nausea and Vomiting
- Raised temperature
- Red and itching skin
- Lowered sperm count (reversible).
Uncommon side effects
The following side effects are seen less often:
- Small bruises on skin
- Gastric distress
- Abdominal pain
- Blood in the urine
- Yellow skin
- Cough, shortness of breath
- Hypersensitivity reaction.
For further information talk to your doctor.