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Progout

Generic Name: Allopurinol
Product Name: Progout

Indication

Allopurinol is used in the following conditions:

  • Treatment and long term control of gout
  • Certain types of kidney stones
  • Kidney disease caused by increased uric acid levels in the urine
  • In patients undergoing chemotherapy or radiotherapy

    Action

    Allopurinol reduces the production of uric acid. If uric acid is present in the body in excessive levels it can produce gout and kidney disease. Certain drugs given in chemotherapy can also increase uric acid levels.

    Dose advice

    Adults:

  • The initial recommended dose is 100 mg once a day
  • This dose may be increased by 100 mg per day each month depending on the patient’s individual response to treatment
  • The usual dose ranges from 100-300 mg per dayPatients with impaired renal function:
  • Moderate renal impairment: 100 mg once a day
  • Severe renal impairment: 100 mg on alternate days.Hyperuricemia due to chemotherapy:
  • Adults: 600-800 mg per day given for 2-3 days before chemotherapy commences. The dose may then be reduced depending on the patient’s individual response to treatment
  • Children: 10-20 mg/kg per day given as one or two divided doses. A maximum dose of 600 mg per day should not be exceeded.

    Schedule

    S4

    Common side effects

  • Rash
  • Itching of skin

    Uncommon side effects

  • Nausea and Vomiting
  • Taste disturbances
  • Diarrhoea
  • Abdominal pain
  • Headache
  • Drowsiness
  • Dizziness
  • Aching joints

     

    For further information talk to your doctor.

  • Dates

    Posted On: 22 July, 2003
    Modified On: 30 January, 2014


    Created by: myVMC
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