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Panzytrat 25000

Generic Name: Amylase; Lipase; Pancrelipase; Protease
Product Name: Panzytrat 25000

Indication

Used to replace pancreatic enzymes in conditions in which they are lacking (pancreatic exocrine insufficiency (PEI)):
- cystic fibrosis
- chronic pancreatitis
- post-pancreatectomy
- post-gastrointestinal bypass surgery
- ductal obstruction.
Panzytrat 25000 is only for use in patients older than 18 months.

Action

The body requires enzymes released by the pancreas in order to properly digest foods. Pancrease replaces these enzymes in the duodenum, the place they would usually be released, and normal digestion can take place. Proper digestion is important to ensure the body receives all the nutrients contained in food.

Dose advice

Dosage of Panzytrat 25000 must be individualised to each patient and is determined based on symptoms and fat content of diet. Start with a low dose and adjust according to stool studies over three days.
Panzytrat 25000 capsules should be taken with food and plenty of water should be drunk to maintain hydration. If swallowing of capsules is a problem, they can be opened and microtablets sprinkled on pH neutral food (banana, apricot, sweet potato, applesauce, instant pudding) and eaten immediately.
Enzyme activity is destroyed if microtablets come in contact with anything with an alkaline pH (including stomach contents after antacid ingestion).
Recommended dosing regimes are as follows:
Adults
- initially 1 capsule with every meal and snack (approx 6 capsules per day)
- individual variation may require higher dosing
- maximum daily lipase dose: 20,000 BP units/kg
Children > 18months
- initially 1 capsule with every meal and snack (approx 4 capsules per day)
- individual variation may require higher dosing
- maximum daily lipase dose: 20,000 BP units/kg
Children > 18months with cystic fibrosis
- do not exceed 6,000 BP units/kg/meal

Schedule

S4

Common side effects

- nausea
- vomiting
- abdominal pain

Uncommon side effects

- diarrhoea
- abnormal stools
- constipation
- allergic or hypersensitivity reaction of the skin

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 22 July, 2003


Created by: myVMC