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Minax

Generic Name: Metoprolol tartrate
Product Name: Minax

Indication

Minax is used for:

  • High blood pressure
  • Angina
  • Tachyarrhythmias
  • Heart Attack
  • Prevention of migraine

    Action

  • Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.
  • The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretionmay also contribute.
  • The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.
  • The antiarrhythmic properties are due to antisympathetic effects: depression ofsinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.
  • Atenolol, a beta-1-selective blocker, has ahigher affinity for beta-1 receptors in the heart with less effect on beta-2 receptorsin bronchi and peripheral vasculature.

    Dose advice

    Hypertension:

  • Oral: initially 50-100mg once daily for 1 Week; maintenance 50-100mg once or twice daily.Angina:
  • Oral: initially 25-50mg twice daily; maintenance 50-100mg 2-3 times daily
  • Tachyarrhythmias:
  • Oral: 50-100mg 2-3 times dailyIV:
  • 5mg (1mg/minute), repeated at 5 Minute intervals up to a maximum of 20mgMyocardial infarction:
  • Initially, IV 5mg at 5 minute intervals to a total of 15mg, then 25-50mg orally every 6 hours for 48 hours.
  • Maintenance, oral 50- 100mg twice daily.Prevention of migraine
  • Oral: 50-75mg twice daily.

    Schedule

    S4

    Common side effects

  • Nausea
  • Diarrhoea
  • Bronchospasm
  • Dyspnoea
  • Cold extremities
  • Exacerbation of Raynaud’s syndrome
  • Bradycardia
  • Hypotension
  • Heart failure
  • Heart block
  • Fatigue
  • Dizziness
  • Abnormal vision
  • Decreased concentration
  • Hallucinations
  • Insomnia
  • Nightmares
  • Depression
  • Altered glucose and lipid metabolism

    Uncommon side effects

  • Rash
  • Exacerbation of psoriasis
  • Impotence
  • muscle cramp
  • Acute urinary retention
  • Nasal congestion
  • Hypersensitivity reaction
  • Thrombocytopenic purpura
  • Liver function abnormality
  • Alopecia
  • Cardiac arrest
  • Hepatic injury

     

    For further information talk to your doctor.

  • Dates

    Posted On: 22 July, 2003
    Modified On: 13 March, 2014


    Created by: myVMC
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