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Metronide

Generic Name: Metronidazole
Product Name: Metronide

Indication

Metronide is used to treat serious infections caused by anaerobic bacteria or protozoa (see Action Description for full list). Some of these infections include:- Blood infection.- Brain abscess.- Necrotising pneumonia.- Bone infection.- Postpartum sepsis.- Pelvic abscess.- Pelvic skin infection.- Postoperative wound infections.Metronide’s anti-protozoal action is useful in treating:- Urogenital trichomoniasis.- Bacterial vaginosis.- Intestinal and extraintestinal amoebiasis.- Giardiasis.- Acute ulcerative gingivitis.In the treatment of any infection, it is important to isolate the infective organism and its anti-microbial susceptibilities if possible before commencing treatment

Action

Metronidazole is an antibiotic agent with activity against anaerobic (non-oxygen using) bacteria and protozoa. It kills anaerobic bacteria by a mechanism thought to be interfering with the production of DNA. Anaerobic bacteria susceptible to Metronidazole include:- Bacteroides fragilis.- Other Bacteroids.- Fusobacterium.- Eubacterium.- Clostridium.- Anaerobic Streptococci.Disease-causing protozoa that are killed by Metronidazole include:- Trichomonas vaginalis.- Other trichomonads.- Entamoeba histolytica.- Giardia Lamblia.- Balantidium coli.- Causative organisms of active ulcerative gingivitis.

Dose advice

- Maximum dose is 4g/24hour period.- Tablets must be swallowed whole, not chewed or crushed.- Tablets should be taken during or after meals.Anaerobic infections iV treat for 7 days:Adults and children >12:- 400mg three times a day. Children 7-12 years:- 200mg three times a day. Children 3-7 years:- 100mg four times a day.Children 1-3 years:- 100mg three times a day.Urogenital trichomoniasis:Adults and children >12:- 200mg three times a day for 7 days; or- One 2g dose once.Children 7-12 years:- 100mg three times a day for 7 days.Children 3-7 years:- 100mg twice a day for 7 days.Children 1-3 years:- 50mg three times a day for 7 days.Bacterial vaginosis:Adults and children >12:- One 2g dose once; or- 400mg three times a day for 7 days.Amoebiasis iV treat for 5-10 days:Adults and children >12:- 400-800mg three times a day, depending on severity.Children 7-12 years:- 200-400mg three times a day, depending on severity.Children 3-7 years:- 100-200mg four times a day, depending on severity.Children 1-3 years:- 100-200mg three times a day, depending on severity.Giardiasis iV treat for 3 days:Adults and children >12:- 2g once daily.Children 7-12 years:- 1g once daily.Children 3-7 years:- 600mg once daily.Children 1-3 years:- 400mg once daily.Acute ulcerative gingivitis iV treat for 3 days:Adults and children >12:- 200mg three times a day.Children 7-12 years:- 100mg three times a day.Children 3-7 years:- 100mg twice a day.Children 1-3 years:- 50mg three times a day.Bacterial prophylaxis in surgery:Metronide tablets are not considered to be an appropriate formulation for surgical prophylaxis. An intravenous preparation, such as Metronidazole Intravenous Infusion, should be used instead.

Schedule

S4

Common side effects

Being an oral form of Metronidazole, Metronide is well tolerated. The most common side effects are primarily gastrointestinal and include:- Nausea.- Headache.- Loss of appetite loss.- Furry tongue.- Dry mouth.- Inflamed tongue.- Sharp, unpleasant metallic taste.- Vomiting and diarrhoea (less often).

Uncommon side effects

Some less common reactions include:- Epigastric pain.- Abdominal cramping.- Constipation.- Oral cavity inflammation.- Vertigo.- Tinnitus.- Hives, itching skin.- Flushing.- Reduction in white blood cell count iV reversible with withdrawal of drug.- Joint pains.- Nasal congestion.

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 30 January, 2014


Created by: myVMC
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