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Metrogyl

Generic Name: Metronidazole
Product Name: Metrogyl

Indication

Metronidazole is used to treat the following types of infections:

  • Certain types of bacterial infections
  • Protozoal infections
  • Pseudomembranous colitis
  • Dental infections, including acute gingivitis
  • Intra-abdominal infections
  • Aspiration pneumonia
  • Lung abscess
  • Bacterial vaginosis
  • Pelvic inflammatory disease
  • Amoebiasis
  • Eradications of helicobacter pylori bacteria, which is responsible for causing peptic ulcer disease
  • Prevention of infections during and following surgery.

Action

Metronidazole is thought to act by interfering with DNA synthesis in bacteria.

Dose advice

Adults:

Oral dosing: 200-400 mg every 8-12 hours up to a maximum dose of 4 g daily.

Rectal dosing: 1 g every 8-12 hours.

Children:

5 mg/kg every 8 hours given orally or intravenously.

Rectal dosing:

Children aged 1-5 years: 250 mg 3 times a day.

Children aged 6-12 years: 500 mg three times day.

For severe infections:

500 mg intravenously every 8-12 hours to a maximum dose of 4mg a day.

Pseudomembranous colitis:

Adults: 400 mg orally three every 8 hours for 7-10 days.

Children: 10 mg/kg orally every 8 hours for 7-10 days.

Surgical prophylaxis:

Adults

Intravenous infusion: 500 mg with the infusion ending at the time of induction.

Rectal dosing: 1 g given as a single dose 8 hours prior to surgery.

Oral dosing: 400 mg given as a single dose 1-2 hours prior to surgery.

Children

12.5 mg/kg given intravenously to a maximum dose of 500 mg. The infusion should end at the time of induction

Acute intestinal amoebiasis:

Adults: 600-800 mg orally every 8 hours for 6-10 days.

Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 6-10 days.

The treatment course can be repeated after 2 weeks if necessary.

Extra-intestinal amoebiasis:

Adults: 600-800 mg orally every 8 hours for 10-14 days.

Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 10-14 days.

Bacterial vaginosis:

400 mg orally twice a day for 5 days.

Trichomoniasis:

2 g orally given as a single dose. If this fails 400 mg should be given twice daily for 5 days.

In women who are pregnant or lactating the 5-day course should be used.

Sexual partners also need to be treated.

Giardiasis:

Adults: 2 g orally for 3 days. If this fails, 400 mg should be given every 8 hours for 7 days.

Children: 30 mg/kg up to a maximum of 2g given orally once a day for 3 days or, if this fails, 10 mg/kg should be given 3 times a day for 7 days.

Schedule

S4

Common side effects

  • Nausea
  • Diarrhoea
  • Metallic taste
  • Inflammation and clotting of veins if given intravenously.

Uncommon side effects

  • Allergic reactions including rash, itch, flushing and fever
  • Headache
  • Dizziness
  • Vomiting
  • Inflammation of the tongue
  • Sores around and in the mouth
  • Dark coloured urine
  • Loss of sensation.

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 1 January, 1970

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Created by: myVMC