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Metrogyl

Generic Name: Metronidazole
Product Name: Metrogyl

Indication

Metronidazole is used to treat the following types of infections:- Certain types of bacterial infections.- Protozoal infections.- Pseudomembranous colitis. – Dental infections, including acute gingivitis.- Intra-abdominal infections.- Aspiration pneumonia.- Lung abscess.- Bacterial vaginosis.- Pelvic inflammatory disease.- Amoebiasis.- Eradications of helicobacter pylori bacteria, which is responsible for causing peptic ulcer disease.- Prevention of infections during and following surgery.

Action

Metronidazole is thought to act by interfering with DNA synthesis in bacteria.

Dose advice

Adults:- Oral dosing: 200-400 mg every 8-12 hours up to a maximum dose of 4 g daily.- Rectal dosing: 1 g every 8-12 hours.Children:- 5 mg/kg every 8 hours given orally or intravenously.- Rectal dosing: – Children aged 1-5 years: 250 mg 3 times a day.- Children aged 6-12 years: 500 mg three times day.For severe infections:-500 mg intravenously every 8-12 hours to a maximum dose of 4mg a day.Pseudomembranous colitis:- Adults: 400 mg orally three every 8 hours for 7-10 days.- Children: 10 mg/kg orally every 8 hours for 7-10 days.Surgical prophylaxis:Adults:- Intravenous infusion: 500 mg with the infusion ending at the time of induction.- Rectal dosing: 1 g given as a single dose 8 hours prior to surgery.- Oral dosing: 400 mg given as a single dose 1-2 hours prior to surgery.Children:- 12.5 mg/kg given intravenously to a maximum dose of 500 mg. The infusion should end at the time of induction Acute intestinal amoebiasis:- Adults: 600-800 mg orally every 8 hours for 6-10 days. – Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 6-10 days.The treatment course can be repeated after 2 weeks if necessary.Extra-intestinal amoebiasis:- Adults: 600-800 mg orally every 8 hours for 10-14 days. – Children: 15 mg/kg orally every 8 hours to a maximum dose of 800 mg every 8 hours given for 10-14 days. Bacterial vaginosis:- 400 mg orally twice a day for 5 days.Trichomoniasis:-2 g orally given as a single dose. If this fails 400 mg should be given twice daily for 5 days. – In women who are pregnant or lactating the 5-day course should be used.- Sexual partners also need to be treated.Giardiasis:- Adults: 2 g orally for 3 days. If this fails, 400 mg should be given every 8 hours for 7 days.- Children: 30 mg/kg up to a maximum of 2g given orally once a day for 3 days or, if this fails, 10 mg/kg should be given 3 times a day for 7 days.

Schedule

S4

Common side effects

- Nausea.- Diarrhoea.- Metallic taste.- Inflammation and clotting of veins if given intravenously.

Uncommon side effects

- Allergic reactions including rash, itch, flushing and fever.- Headache.- Dizziness.- Vomiting.- Inflammation of the tongue.- Sores around and in the mouth.- Dark coloured urine.- Loss of sensation.

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 30 January, 2014


Created by: myVMC
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