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Imdur Durules

Generic Name: Isosorbide mononitrate
Product Name: Imdur Durules


Prophylaxis for angina.


Isosorbide mononitrate reduces the end diastolic pressure and volume leading to an improvement in the subendocardial blood flow. The net result is reduced workload for the heart by producing venous and arterial dilatation and an improvement in oxygen supply. Natural initiator of vascular relaxation is endothelium derived relaxing factor, which has the characteristics of nitric oxide. Organic nitrates are metabolised to nitric oxide and they are thought to be the physiological substitute for endothelium derived relaxing factor.

Dose advice

  • One 60mg tablet daily.
  • Dose may be increased to two tablets (120mg) daily – both tablets need to be taken at the same time.
  • Isosorbide mononitrate Sustained Release tablets should not be administered twice daily. The Sustained Release tablets should not be crushed or chewed and should be swallowed whole with fluid.
  • Isosorbide mononitrate Sustained Release tablets are not recommended for management of acute attacks of angina pectoris.
  • Most common symptom of overdose is a pulsing headache. Emesis should be induced and then activated charcoal should be administered. In cases of severe hypotension, patient should be placed in supine position with legs raised.



    Common side effects

  • Headache.

    Uncommon side effects

  • Tiredness
  • Sleep disturbance
  • Gastrointestinal disturbances
  • Hypotension
  • Poor appetite
  • Nausea
  • Tachycardia
  • Heartburn
  • Vertigo


    For further information talk to your doctor.

  • Dates

    Posted On: 22 July, 2003
    Modified On: 30 January, 2014

    Created by: myVMC
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