Generic Name: Doxycycline hydrochloride
Product Name: Doxy Tablets
Used in the treatment of infections caused by micro-organisms susceptible to Doxycycline. Including:
- Primary atypical pneumonia
- Rickettsial infections
- Trachoma & inclusion conjunctivitis
- Lymphogranuloma venereum
- Used in the treatment of severe acne
- Used in the chemoprophylaxis of malaria, in conjunction with other agents.
- Doxycycline stops the growth of a variety of micro-organisms that cause infections in humans
- Doxycycline is essentially totally absorbed from the gut, the presence of food or milk does not affect absorption. Peak concentrations are reached in about 2.7 hours.
- Doxycycline is concentrated by the liver in the bile, and excreted in its active form, in the urine and faeces. Most of the drug is eliminated from the body within 72 hours. Excretion is prolonged in patients with impaired renal function, however serum half life is not significantly different between patients with normal renal function and those with severely impaired renal function, ranging between 18-22 hours.
Adults, Children >8 years (and > 50 kg)
- 100 mg every 12 hours on the first day of treatment.
- Followed by 100 mg/day (e.g. as a single dose or as 50 mg twice daily).
- Severe infections (e.g. chronic infections of the urinary tract) may warrant doses of 100 mg every 12 hours.
Acute uncomplicated gonococcal infections: 100 mg, twice daily, for 5-7 days.
Primary & secondary syphilis: 300 mg/day, in divided doses, for at least 10 days.
Louse borne typhus: 100-200 mg, stat.
Prevention of scrub typhus: 200 mg stat.
Children > 8 years (and < 50 mg, but without skeletal growth retardation)
Severe acne: 50 mg/day, for 12 weeks.
Malaria chemoprophylaxis: 100 mg, once daily, commencing two weeks prior to entering, during, and two after leaving the at risk malarious area. (The safety of taking 100 mg/day for periods of greater than 8 weeks has not been established, and therefore a maximum of 8 weeks is recommended.)
Use in pregnancy
(Category D) Safe for use in the first 18 weeks of pregnancy, after which they cause teeth discolouration in the baby and accumulate in the growing skeleton. Avoid use in pregnant women, or those women likely to become pregnant.
Use in lactation
Doxycycline is excreted in breast milk. It may cause permanent teeth discolouration during teeth development, and has been liked to reduced bone growth rates in premature infants. Do not use in breast feeding women.
Common side effects
- Photosensitivity dermatitis
- Nail disease
- Abdominal pain
- Local reaction at injection site.
Uncommon side effects
For further information talk to your doctor.