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Generic Name: Azathioprine
Product Name: Azapin

Indication of Azapin

Azathioprine is used for the following conditions:
Suppression of the immune system in
Severe rheumatoid arthritis
Dermatomyositis and polymyositis
Autoimmune hepatitis
Pemphigus vulgaris
Polyarteritis nodosa
Autoimmune haemolytic anaemia
Autoimmune thrombocytopenic purpura
Prevention of organ transplant rejection
Inflammatory bowel disease
Behcet’s syndrome

Action of Azapin

Azathioprine suppresses the immune system and reduces inflammation

Dose advice of Azapin

The hematologic response should be monitored to guide dosing. Bone marrow suppression will limit the dose that can be given
The initial recommended dose is 2–3 mg/kg once daily given either orally or intravenously
Maintenance dosing is1–3 mg/kg or the minimum dose required to control the disease or prevent transplant rejection.

Renal impairment: Dose reductions may be necessary.
Hepatic impairment: Dose reductions may be necessary

Common side effects of Azapin

Increased susceptibility to viral, fungal and bacterial infections
Hair loss
Nausea and vomiting
Loss of appetite
Mouth ulceration
Inflammation of the Oesophagus
Skin rashes

Uncommon side effects of Azapin

Severe anaemia
Allergic reactions such as
Muscle and joint aches,
Shortness of breath
Low blood pressure
Abnormal liver function
Abnormal heart rhythm
Kidney dysfunction
Increased risk of skin cancers and certain other types of cancer


For further information talk to your doctor.


Posted On: 3 September, 2004
Modified On: 1 January, 1970

Created by: myVMC