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Alprim

Generic Name: Trimethoprim
Product Name: Alprim

Indication

Used for the treatment of acute urinary tract infections caused by organisms susceptible to Trimethoprim

Action

Microbiology.

Trimethoprim inhibits bacterial nucleic acid and protein biosynthesis.
It is active against the pathogens commonly responsible for urinary tract infections (e.g. E.coli, P.mirabilis, K.pneumoniae).
Trimethoprim is found in vaginal secretions and faeces, and can suppress normal vaginal and bowel flora.
It is not active against Pseudomonas sp.
Developing resistance is more likely to occur in hospital than in domicillary use.

Pharmacokinetics.

Trimethoprim is rapidly absorbed from the gut, with a half life of 8-12 hours (in patients with normal renal function).
Excretion is primarily in the urine, 80% of the dose is excreted unchanged.

Dose advice

Adults.
1 tablet, daily, for 7 days

Children
6 â?? 12 years: Half a tablet, daily, for 7 days.
< 6 years: The appropriate dose in children of this age is not yet established.

Impaired renal or hepatic function.
Use with caution in patients with renal or hepatic insufficiency.

Use in pregnancy
Category B3

Use in lactation.
Trimethoprim is excreted in breastmilk, it should not be used in breastfeeding women.

Schedule

S4

Common side effects

Rash, pruritus.
Nausea, vomiting, abdominal discomfort, glossitis.
Low blood counts (thrombocytopenia, leucopenia, neutropenia, megaloblastic anaemia), methaemoglobinaemia
Vaginal candidiasis.

Uncommon side effects

Fever
Changes in hepatic and renal biochemistry.

 

For further information talk to your doctor.

Dates

Posted On: 22 July, 2003
Modified On: 22 July, 2003


Created by: myVMC
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