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Actilyse

Generic Name: Alteplase
Product Name: Actilyse

Indication of Actilyse

Alteplase belongs to a group of medicines known as fibrinolytics. Alteplase breaks down unwanted blood clots, for example, in the lungs (called a pulmonary embolism). It is also given intravenously as soon as possible after the onset of a heart attack to dissolve clots in the arteries of the heart wall. This reduces the amount of damage to the heart muscle. Actilyse can be given to dissolve clots in the vessels in the brain, for example, those which cause strokes.

Action of Actilyse

Alteplase belongs to a group of medicines known as fibrinolytics. It works by attaching to a blood clot and stimulating extra production of a substance produced naturally by the body called plasmin. Plasmin is produced in the blood to break down the major constituent of blood clots (fibrin), thereby dissolving clots once they have fullfilled their purpose in stopping bleeding. Extra production of plasmin caused by alteplase breaks down unwanted blood clots, for example, in the lungs (pulmonary embolism).

Dose advice of Actilyse

This is a drug that is given intravenously in hospital. Acute myocardial infarction:

  • 3-hour IV infusion
    • The recommended regime is a 10 mg bolus, then 50 mg over the first hour and 40 mg over the following 2 hours (for patients <65 kg adjust dosage so total dose does not exceed 1.5 mg/kg). Accelerated IV infusion:
    • Recommended is a 15 mg bolus, then 50 mg over 30 minutes and 35 mg over the next 60 minutes (for patients <65 kg adjust dosage so total dose does not exceed 1.5 mg/kg). Pulmonary embolism:
    • The recommended dose is 10 mg IV bolus, then 90 mg IV infusion over 2 hours (for patients <65 kg adjust dosage so total dose does not exceed 1.5 mg/kg). Acute ischaemic stroke:
    • IV bolus of 0.1 mg/kg followed by 0.8 mg/kg infused over 60 minutes (to a maximum total dose of 90 mg).
  • Schedule of Actilyse

    Schedule 4

    Common side effects of Actilyse

    Common side effects include:

  • bleeding, including bleeding at injection sites, intracerebral bleeding, internal bleeding (for example, gastrointestinal tract, genitourinary tract).
  • Uncommon side effects of Actilyse

    Allergic reactions including:

  • fever.
  • chills.
  • rash.
  • nausea.
  • headache.
  • bronchospasm.
  • anaphylaxis.
  • vasculitis.
  • nephritis.
  • hypotension.
  • References

    [1] AMH Pty Ltd. Actilyse. Australian Medicines Handbook: July 2005. [2] MIMS Australia Pty Ltd. Actilyse. MIMS Online 2003. Available from: http://www.mims.com.au

     

    For further information talk to your doctor.

    Dates

    Posted On: 22 July, 2003
    Modified On: 13 March, 2014


    Created by: myVMC